Vismodegib y la vía del Sonic Hedgehog

Gestión del conocimiento en la micro y pequeña empresa mexicana de la industria del software

Resumen. Las empresas que desarrollan software en México son microempresas con diez o menos empleados que no cuentan con sistemas de gestión del conocimiento. Se parte de un modelo de transferencia de conocimiento de los desarrolladores expertos a los no expertos, a través de un sistema de gestión del conocimiento. Se enfocó la investigación en conocer ¿Cómo sucede la gestión de conocimiento en...

Las TICs y la Asociatividad Comercial: El Caso de la Ruta del Vino del Maule

Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib.

Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is rare in adults. Medulloblastomas fall into 4 prognostically significant molecular subgroups that are best defined by experimental gene expression profiles: the WNT pathway, sonic hedgehog (SHH) pathway, and subgroups 3 and 4 (non-SHH/WNT). Medulloblastoma of adults belong primarily to the SHH category. Vi...

Sonic hedgehog

Are there related proteins? Lots. In mammals, Sonic is related to two other hedgehogs: Indian and Desert. When expressed appropriately, the three proteins can substitute for one another but they do have unique functions: Desert hedgehog is needed for spermatogenesis and Indian hedgehog regulates cartilage differentiation. In the zebrafish, Sonic is related to Tiggywinkle hedgehog — which is tho...

La doctrina y el laboratorio: fisiología y experimentación en la sociedad española del siglo XIX

Vivian Nutton, in the first chapter, wrote a 43 page essay on the social history of medicine in ancient Greece and Rome that is the best introduction to this vast topic I have seen. Katharine Park's description of medicine and society in medieval Europe, a society more diverse than our own, she claims, tells us about a universe of disease and the various attempts to cope with the effects of suc...